Over expression of AdeABC and AcrAB-TolC efflux systems confers tigecycline resistance in clinical isolates of Acinetobacter baumannii and Klebsiella pneumoniae
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چکیده
منابع مشابه
Over expression of AdeABC and AcrAB-TolC efflux systems confers tigecycline resistance in clinical isolates of Acinetobacter baumannii and Klebsiella pneumoniae.
INTRODUCTION Due to the wide use of tigecycline in the treatment of severe infections caused by multidrug-resistant (MDR) bacteria, clinical resistance to tigecycline has increased in recent years. Here, we investigated the relationship between tigecycline resistance and the expression of efflux pumps. METHODS Clinical isolates of Acinetobacter baumannii and Klebsiella pneumoniae were consecu...
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Sir, Tigecycline is a therapeutic option for multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae infections. Recently, tigecycline-non-susceptible A. baumannii and K. pneumoniae have been reported in patients receiving tigecycline. Despite several reports concerning in vitro and in vivo susceptibility of bacterial pathogens to tigecycline, there is a paucity of data regarding ...
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متن کاملMechanisms of tigecycline resistance among Klebsiella pneumoniae clinical isolates.
Of 26 tigecycline-nonsusceptible Klebsiella pneumoniae (TNSKP) clinical isolates, 25 had nonsynonymous mutations in ramR and/or acrR (23 in ramR and 10 in acrR). Eight TNSKP isolates possessed overexpression of ramA, acrB, rarA, and oqxB simultaneously, while 8 and 1 TNSKP strains had upregulation of ramA and acrB and of rarA and oqxB, respectively. Thus, resistance mechanisms of 9 TNSKP isolat...
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ژورنال
عنوان ژورنال: Revista da Sociedade Brasileira de Medicina Tropical
سال: 2016
ISSN: 0037-8682
DOI: 10.1590/0037-8682-0411-2015